Webinars & Workshops

Tuesday, April 29, 2014 @ 12:00 pm – 1:30 pm EST

Discover epigenomic variation with a flexible targeted bisulfite sequencing method

Epigenetic researchers face a number of challenges in methylation studies related to breadth, depth, throughput and more. Built on Roche NimbleGen’s proprietary probe design and manufacturing technologies, the SeqCap Epi Enrichment System will enable you to overcome these challenges.

Dr. Burgess and Dr. Springer will discuss how innovative probe design combined with a unique workflow provides a clearer picture than any other system currently available of the epigenomic variation in samples. See how you can discover differential methylation efficiently, with custom designs over target selection, lower sample input, higher information retention, and the abilities to capture both strands, detect complex or rare methylation events and reduce false positives.

The presenters will share the rationale behind the development of this flexible targeted bisulfite sequencing tool and how it has been applied in methylation research.

DNA Samples

  • Target Enrichment


    Daniel Burgess, PhD, Group Leader Sequence Capture
    - Roche NimbleGen

    Dr. Burgess holds a PhD degree from the Department of Human Genetics at the University of Michigan. He was a Postdoctoral Fellow and then an Assistant Professor of Neurology at Baylor College of Medicine in Houston, Texas. Dr. Burgess joined Roche NimbleGen in 2008, where he has been leading efforts in target enrichment technology and product development for high resolution genome analysis.

  • Target Enrichment


    Nathan Springer, PhD Professor
    - University of Minnesota

    Nathan Springer performed his PhD research on the consequences of aneuploidy in Dr. Ron Phillips group at the University of Minnesota. He was a post-doctoral researcher in Dr. Shawn Kaeppler's group at the University of Wisconsin where he worked on the characterization of chromatin-related genes in maize. He joined the Department of Plant Biology at the University of Minnesota in 2003. He is currently a Professor in the Department of Plant Biology and the Director of the Microbial and Plant Genomics Institute. Nathan's research group studies natural variation in maize with focuses on structural genomic variation, gene expression variation and epigenomic variation.

Discover more, sequence less using SeqCap EZ Library. Learn more from our workshops & webinars listed below.

Roche NimbleGen Webinar Series

Date Topic Speaker Watch Now
February 5, 2014 Unleash the potential of your DNA samples with an optimized target enrichment workflow for next-generation sequencing Dr. Dan Burgess & Maryke Appel, Kapa Biosystems (Click to watch)
October 16, 2013 Efficient SNP Discovery for Crop Genomes through Exome Sequencing Patrick Schnable & Eduard Akhunov & Nils Stein (Click to watch)
Date Topic Speaker Download Audio Podcast Download Video Podcast View Flash Movie
October 31, 2012 Expanding the SeqCap EZ Library Portfolio: targeted disease panels and the next generation of exome capture solutions Marilou Wijdicks & Dr. Dan Burgess Download Audio Podcast Download Video Podcast View Flash Movie
August 18, 2011 Exome Sequencing Strategies in Genetically Heterogeneous Conditions Dr. Stephan Zuchner Download Audio Podcast Download Video Podcast View Flash Movie
August 11, 2011 Robotic Automation of Sequence Capture Resequencing Made EZ Marilou Wijdicks, Roche NimbleGen
& Jeremy Lambert, Caliper Life Sciences
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June 30, 2011 Genome-wide Studies of Copy Number Variation and Exome Sequencing Identify Rare Variants in BAG3 as a Cause of Dilated Cardiomyopathy Dr. Nadine Norton & Dr. Ray Hershberger,
University of Miami
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May 6, 2010 Targeted Re-Sequencing Made Easy: A Core Laboratory’s Experience with NimbleGen SeqCap EZ Casey Matthews,
NCI-CGF Scientific Operations Team
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Feb 18, 2010 Introducing the NimbleGen ChIP-chip and DNA Methylation Multiplex Arrays Dr. Ken Lo,
Roche NimbleGen
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Jul 29, 2009 Introducing the NimbleGen MS 200 Microarray Scanner for Analysis of High-Density DNA Microarrays Abigail Farfan,
Roche NimbleGen
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Jun 18, 2009 Methylation Profiling in Uniparental Tissues Identifies Novel Imprinted Genes Dr. Andrew Sharp,
University of Geneva, Switzerland
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Apr 9, 2009 Introducing the High-Resolution, High-Sensitivity NimbleGen 2.1M DNA Methylation Arrays Dr. A. Leonardo Iniguez,
Roche NimbleGen
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Jan 15, 2009 NimbleGen Sequence Capture Using the HD2 Platform: Exome Capture Made Easy Dr. Dan Burgess,
Roche NimbleGen
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Nov 6, 2008 Introducing NimbleGen HD2 Arrays for High-Resolution ChIP-chip Analysis Dr. A. Leonardo Iniguez,
Roche NimbleGen
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Apr 3, 2008 Sequence Capture Technology: Using Microarrays to Capture Megabases of Sequence or Hundreds of Thousands of Human Exons for Next Generation Sequencing Dr. Tom Albert,
Roche NimbleGen
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Mar 19, 2008 Genomic Analyses of Gene Regulation by Poly(ADP-Ribose) Polymerase-1 and Histone H1 Dr. Matt Gamble,
Cornell University
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Feb 28, 2008 Integrated Epigenomic Analyses of Neuronal MeCP2 Reveal a Role for Long-Range Interaction with Active Genes Dr. Janine LaSalle,
UC Davis
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Nov 29, 2007 Genome Architecture and Genomic Disease: A Targeted Approach to Disease Discovery Dr. Heather Mefford
University of Washington
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Nov 1, 2007 Demonstration of KAP1 Binding to Silenced Chromatin with Genome-wide ChIP-chip Analysis Dr. Henriette O'Geen
University of California, Davis
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Sep 19, 2007 Gene Silencing by Large, Non-coding RNAs: The Regulatory Role of HOTAIR analyzed with ChIP-chip and Tiling Expression Analysis Dr. John Rinn, Harvard Medical School Download Audio Podcast Download Video Podcast View Flash Movie
Aug 15, 2007 Assaying Gene Expression Using NimbleGen Multiplex Arrays: Taking Advantage of High-Throughput Sample Analysis Dr. John Manak, Roche NimbleGen Download Audio Podcast Download Video Podcast View Flash Movie
Jul 18, 2007 Genome-Wide Distribution, Sequence Determinant and Evolution of CTCF Binding Dr. Tae Hoon Kim, Yale University School of Medicine Download Audio Podcast Download Video Podcast View Flash Movie
May 8, 2007 Microarray-Mediated, Whole-Genome Comparison of the Distribution of RNA Polymerase with the Transcript Map in Escherichia coli Dr. Joseph Wade, Harvard University Download Audio Podcast Download Video Podcast View Flash Movie
Apr 11, 2007 Part I: A novel genomic disorder affecting neurobehavioral development; fine mapping of rearrangements involving complex low copy repeats on chromosome 10q Dr. Scott Selleck, The University of Minnesota Download Audio Podcast Download Video Podcast View Flash Movie
Apr 11, 2007 Part II: Using Drosophila to model disruptions of PTEN-TSC-TOR signaling on synapse assembly and behavior Dr. Scott Selleck, The University of Minnesota Download Audio Podcast Download Video Podcast View Flash Movie
Mar 13, 2007 Efficient High-Resolution Deletion Discovery in Caenorhabditis elegans by Array CGH Dr. Jason Maydan, UBC, Vancouver, BC, Canada Download Audio Podcast Download Video Podcast View Flash Movie
Mar 6, 2007 Using High-Resolution ChIP-chip to Model Chromatin Signatures of Promoters and Enhancers in the Human Genome Dr. Nathaniel Henitzman, LICR, UCSD Download Audio Podcast Download Video Podcast View Flash Movie
Feb 15, 2007 High-Resolution Mapping of Copy-Number Variants Genome-Wide with Array CGH Timothy A. Graubert, M.D. Washington University, St. Louis Download Audio Podcast Download Video Podcast View Flash Movie
Jan 24, 2007 Genome-Wide DNA Methylation Analysis with Immunoprecipitation and Tiling DNA Microarrays Dr. Daniel Zilberman, Fred Hutchinson Cancer Research Center Download Audio Podcast Download Video Podcast View Flash Movie
Aug 31, 2006 The Discovery and Characterization of Genomic Disorders with High-Resolution Array CGH Dr. Andrew Sharp, The University of Washington Download Audio Podcast Download Video Podcast View Flash Movie
Aug 8, 2006 AHigh-Resolution Method to Identify DNase I Hypersensitive Sites Using Tiled Microarrays Dr. Greg Crawford, Duke University Download Audio Podcast Download Video Podcast View Flash Movie
May 16, 2006 Genome-Wide Mapping of Transcriptional Regulatory Elements in Mammalian Cells Dr. Bing Ren, UCSD Download Audio Podcast Download Video Podcast View Flash Movie
Feb 6, 2006 Identifying Antibiotic Resistance and Other Adaptive Mutations in Helicobacter pylori using NimbleGen CGS Technology Dr. Douglas Berg, Washington University Download Audio Podcast Download Video Podcast View Flash Movie

Roche NimbleGen Workshops

Date Venue Topic Speaker Download Audio Podcast Download Video Podcast View Flash Movie
Nov 7, 2012 ASHG 2012 Roche Applied Science: Sequencing Solutions - Introduction Baiju Parikh
Marketing Manager
N/A N/A View Flash Movie
Feb 21, 2011 ABRF 2011 Whole-Exome Capture Bake-Off Dr. Seth Crosby
Washington University
N/A N/A View Flash Movie
A High-Throughput Automated Workflow for NimbleGen SeqCap EZ Exome v2.0 on a Caliper Sciclone NGS Dr. Toumy Guettouche
University of Miami.
N/A N/A View Flash Movie
High-Throughput Exome Sequencing to Analyze Complex Samples Dr. Shawn Levy
HudsonAlpha Institute for Biotechnology
N/A N/A View Flash Movie
Nov 3-4, 2010 ASHG 2010 Identification of a Novel Locus Associated with the Common Birth Defect Spina Bifida Dr. J. Robert Manak
University of Iowa
N/A N/A View Flash Movie
Exonic aCGH for Copy Number Detection in Mitochondrial Diseases Rong Mao
University of Utah
N/A N/A View Flash Movie
Implementing Large-scale Exome Capture to Define Human Sequence Diversity Dr. Mark J. Rieder
University of Washington
N/A N/A View Flash Movie
Exome Sequencing of Multigenerational Mendelian Families Dr. Stephan Zuchner
University of Miami
N/A N/A View Flash Movie
May 25, 2009 ESHG 2009 High Resolution Array CGH in Chronic Myeloid Leukemia Dr. Alistair Reid
Imperial College of London
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Developing an Imprinting Map of the Human Genome Dr. Andrew Sharp
University of Geneva
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Jan 13, 2009 PAG 2009 Whole Genome Analysis of DNA Copy Number Variation in Dogs Dr. Carlos E. Alvarez
Ohio State University
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Discovery of Human Genetic Variations with Sequence Capture Technology Dr. Nathan M. Springer
University of Minnesota
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Nov 12, 2008 ASHG 2008 Copy Number Variation in Low Copy Repeat-Rich Regions of the Genome: How Much is There and What Does it Take to Measure It? Dr. Scott Selleck
University of Minnesota
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Distinct Chromatin Modifications at Enhancers Correlate with Cell Type-Specific Gene Expression in the Human Genome Dr. David Hawkins
University of California - San Diego
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Discovery of Human Genetic Variations with Sequence Capture Technology Matthew Bainbridge
MS Student
Baylor College of Medicine
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Jun 2, 2007 ESHG 2008 High-Throughput Approaches for DNA Methylation Profiling Dr. Stephan Beck
University College London
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Sequence Capture for Medical Sequencing Dr. Daniel Turner
Wellcome Trust Sanger Institute
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Jan 15, 2008 PAG 2008 Genome-Scale Targeted Sequencing and Expression Analysis in Duplicated Genomes Full Program Download Audio Podcast Download Video Podcast View Flash Movie
Direct Genomic Selection by Microarray Hybridization for
High-Throughput Sequencing
Dr. Xinmin Zhang,
Roche NimbleGen
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Insights into the Evolutionary Significance of Whole Genome Duplications Provided by Populus Expression Arrays Dr. Steve DiFazio,
West Virginia University
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Duplicate gene expression evolution in cotton Lex Flagel,
PhD Student
Iowa State University
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Oct 25, 2007 ASHG 2007 Genome-wide scan of copy number variation in autism Dr. Jonathan Sebat
Cold Spring Harbor Laboratory
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Epigenetic Regulation of the HOX Locus by Non-coding RNAs Dr. John Rinn, Harvard Medical School Download Audio Podcast Download Video Podcast View Flash Movie
Jun 18, 2007 ESHG 2007 Human Genetics and Epigenetics:
High-Resolution Discovery with Array CGH, DNA Methylation, and ChIP-chip
Full Program Download Audio Podcast Download Video Podcast View Flash Movie
Towards a comprehensive map of copy number variation in the human genome Dr. Matthew Hurles
The Wellcome Trust Sanger Institute, Cambridge
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Mapping promoter DNA
methylation in mammalian
genomes using oligonucleotide
arrays
Dr. Michaël Weber
Friedrich Miescher Institute for Biomedical Research, Basel
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Combinatorial Effects of Four Histone Modifications in Transcription and Differentiation Dr. Silke Sperling
Max Planck Institute for Molecular Genetics, Berlin
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Oct 10, 2006 ASHG 2006 Human Genetics and Epigenetics: High-Resolution Discovery with Array CGH, DNA Methylation, and ChIP-chip Full Program Download Audio Podcast Download Video Podcast View Flash Movie
The Discovery and Characterization of Genomic Disorders with High-Resolution Array CGH Dr. Andrew Sharp, The University of Washington Download Audio Podcast Download Video Podcast View Flash Movie
Cytosine Methylation Dynamics in Development and Disease Dr. John Greally, Albert Einstein College of Medicine Download Audio Podcast Download Video Podcast View Flash Movie
ChIP-Chip'ing Away at the Functions of Proteins Mutated in Genetic Syndromes Dr. Peter C. Scacheri, Case Western Reserve University Download Audio Podcast Download Video Podcast View Flash Movie

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