• 2µm pixel resolution for optimal scanning of high-density NimbleGen DNA microarrays
• Autoloader for automated batch processing of up to 48 slides for 24-hour unattended operation
• High signal-to-noise for high quality data and confident results
• Integrated barcode reader for sample identification and tracking
• Advanced dynamic autofocus and auto gain for a clear, bright scan every time
• Internal QC reference slide for easy calibration; scan with confidence every time
• Isolated slide magazine and carbon-filtered airflow to reduce degradation of fluorescent dyes
• Upgradeable to ensure compatibility with high-density NimbleGen arrays of today and ultra-high density arrays of tomorrow

Figure 1

Figure 1: Images of a NimbleGen Array. Comparison of a NimbleGen array scanned at 2μm and 5μm resolution. The increased resolution at 2μm scanning enables high data quality and more confident results from high-density NimbleGen microarrays with the flexibility to scan other array formats.

Figure 2

Figure 2: Signal-to-Noise Performance Data. The MS 200 at 2μm resolution provides ~1.4x higher signal-to-noise compared with 5μm resolution scans. This improved resolution provides higher data quality with the reduced noise for more confident results.

Figure 3

Figure 3: CGH Analysis of a Burkitt Lymphoma Sample. Chromosomal copy number gains and losses were identified in a Burkitt Lymphoma research sample referenced against normal genomic DNA using a NimbleGen Human CGH 3x720K Whole-Genome Tiling v3.0 array. A large deletion (from ~8kb – 43Mb) and amplification (from ~47Mb – 110Mb) in chromosome 8, detected by scanning at either 2μm or 5μm resolution, as indicated. The red and blue bars indicate a signal-to-noise ratio of > 6 (red bars) or less than 6 (blue bars). Note that the 2μm scan indicates better signal-to-noise ratios (indicated by more red bars), especially in the region of copy number amplification.

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