Genome-wide association studies (GWAS) have identified hundreds of loci, with regions ranging from a few hundred kilobases to a few megabases, that are associated with human diseases and traits. A major challenge for follow-up studies is to sequence disease-associated regions to identify the causative mutations for these diseases. Due to the large sizes of these regions, traditional technologies, such as PCR and capillary sequencing are time and cost prohibitive.

NimbleGen Sequence Capture 2.1M and 385K arrays provide an ideal solution for targeted enrichment of these disease associated regions. These customizable arrays can be made to target any region or sequence in the human genome, and offer a powerful solution for large-scale targeted resequencing studies to significantly reduce time, labor, and cost while improving data quality.

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