Roche NimbleGen offers three types of targeted designs to suit your DNA Methylation analyses:

• 385K Promoter Plus CpG Island Arrays are single array designs that include all UCSC-annotated CpG islands and with the following promoter regions for all RefSeq gene promoter regions: 1kb (human) and 1.8kb (mouse and rat). DNA methylation positive control regions, such as the HoxA gene cluster, H19/IGF2 cluster, KCNQ1 cluster, and the IGF2R gene are also included on the arrays.
• 385K Targeted Tiling Arrays offer fine tiling (5 bp median probe spacing) of select biologically significant areas. The Human HOX Array tiles through the HoxA, HoxB, HoxC, HoxD, β-globin and Xist genes. The Human and Dog ENCODE arrays tile through the biologically significant ENCODE pilot regions (HoxA, β-globin, Apo among others). The Human ncRNA (non-coding RNA) Array tiles through the promoters of the 462 miRNA genes, 362 snoRNAs and 89piRNA clusters as well as selected ENCODE regions.
• 4x72K ENCODE Arrays offer a higher throughput, lower cost solution for testing the quality of DNA methylation samples before moving to large-scale studies, or for screening focused targeted regions of interest, for up to 4 independent samples per slide. We currently offer a Human (HG17) design.

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