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NimbleGen Instruments

NimbleGen Systems Inc. provides a complete line of instrumentation, kits and consumables specifically designed to facilitate hybridization, washing and drying of NimbleGen DNA microarrays.

12 Bay Hybe Unit

NimbleGen's 4-Bay and 12-Bay (shown above) Hybridization Systems are designed for highly reproducible hybridization conditions with precision controlled temperature and active mixing to provide high sensitivity and specificity hybridization results. The Hybridization Systems are used with NimbleGen Mixers, a line of adhesive sample enclosures that provide containment and active mixing during hybridization, increasing both signal and stringency. The mixers are available in a range of configurations to support current and future single sample and multiwell DNA array formats in both the current 385K and 2.1M feature HD2 arrays.

NimbleGen offers a full line of kits and consumables that complement the Hybridization System. Specifically designed for the efficient, optimized hybridization and washing of NimbleGen arrays they work to produce clean, blemish-free hybridization results.

NimbleGen Hybridization System

A NimbleGen Hybridization System is your lab’s next step in increasing throughput while achieving consistent and reproducible microarray hybridization results. This easy-to-use system provides an active mixing action and constant incubation temperature to improve hybridization uniformity and enhance signal. Its robust and proven design ensures smooth operation every time, while its modular framework facilitates rapid scaleup of your microarray experiments. Choose between the 4-bay model (shown at right) or the 12-bay model (shown at top of page) to meet the throughput demands of your lab, utilizing just one bay or all of them as your day-to-day needs dictate.

Specifications

Capacity 4 slides (4-bay model)
12 slides (12-bay model)
Slide format Standard 1" x 3" (25.4mm x 76.2mm) glass microarray slide
Electrical requirements Power: 210W (heating) / 12W (mixing) (4-bay model)
580W total (12-bay model)
Temperature Ambient Operating Temperature: 16.5 - 27.5°C
Incubation Temperature Range: Ambient to 65°C
Temperature Control Precision: ± 0.5°C
Mixing parameters Four pre-programmed mix modes (4-bay model)
Two pre-programmed mix modes (12-bay model)

Ordering Information

Catalog Number Name Capacity
00825 NimbleGen Hybridization System 4 (110V) 4 slides
00895 NimbleGen Hybridization System 4 (220V) 4 slides
00826 NimbleGen Hybridization System 12 (110V) 12 slides
00896 NimbleGen Hybridization System 12 (220V) 12 slides
00832 Precision Mixer Alignment Tool (PMAT) NA
NimbleGen Mixers

NimbleGen Mixers, which you adhere directly to microarray slides before sample loading and hybridization, are a key component of the NimbleGen Hybridization System. The Mixers allow for a 3-fold reduction of hybridization volume, leading to greater sensitivity and reliable results while economizing on sample requirements. They fit NimbleGen arrays precisely and have been optimized for NimbleGen array dimensions, ensuring uniform signal and high sensitivity with minimal sample volume. Mixers are supplied with your NimbleGen arrays or can be purchased separately.

Advantages

  • 3- to 10-fold increase in sensitivity
  • Consistent and reproducible results
  • Thorough and efficient active mixing
  • Shorter hybridization times
  • Minimal maintenance
NimbleGen Mixers
Name: NimbleGen X1 Mixer
Compatible Arrays: 385K 1-plex
Sample Loading Volume: 16µl
Catalog Number Quantity
00798 5 Mixers
00799 25 Mixers
00800 100 Mixers
Name: NimbleGen X4 Mixer
Compatible Arrays: 385K 4-plex (4 X 72K)
Sample Loading Volume: 8µl
Catalog Number Quantity
00804 5 Mixers
00805 25 Mixers
00806 100 Mixers
Name: NimbleGen HX1 Mixer
Compatible Arrays: HD2 (2.1M) 1-plex
Sample Loading Volume: 41µl
Catalog Number Quantity
00810 5 Mixers
00811 25 Mixers
00812 100 Mixers
 

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