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| Recent Webinars |
 A. Leonardo Iniguez, Ph. D. Senior Scientist, Epigenetics Roche NimbleGen Madison, WI |
Thursday, April 9, 2009 |
Introducing the High-Resolution, High-Sensitivity NimbleGen 2.1M DNA Methylation Arrays Epigenetic mechanisms, such as DNA methylation, play critical roles in the regulation of gene expression. Understanding DNA methylation will not only further our knowledge of gene regulation, but given the connection between epigenetics and disease, it will also increase our understanding of disease development hopefully leading to the creation of diagnostics as well as preventative and therapeutic treatment options. Powerful methods exist to analyze DNA methylation patterns in higher eukaryotes including methylated DNA immunoprecipitation (MeDIP), an affinity based approach to enrich methylated DNA regions from genomic DNA, which can be combined with microarrays to profile genomic DNA methylation patterns. Here we introduce our new, MeDIP-optimized, 2.1M DNA Methylation Array portfolio for human, mouse and rat including our whole genome tiling array sets (10-array sets at 100bp probe spacing or 4-array sets at ~200bp probe spacing) and the Deluxe Promoter Arrays which offer the most comprehensive gene promoter, CpG island, and miRNA promoter coverage available in a single slide array. The new human and mouse DNA methylation arrays also include probes covering positive, negative and nonCpG control regions to aid in assessment of experimental performance. We will demonstrate (1) the comprehensive, sensitive, reproducible DNA methylation analysis possible using MeDIP and the 2.1M DNA Methylation arrays, (2) the utility of the control regions in analyzing MeDIP experimental performance, and (3) the validation of whole-genome MeDIP-chip analysis using bisulphite conversion and sequencing. |
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Roche NimbleGen Webinar Series 
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Topic |
Speaker |
Download Audio Podcast |
Download Video Podcast |
View Flash Movie |
| Apr 9, 2009 |
Introducing the High-Resolution, High-Sensitivity NimbleGen 2.1M DNA Methylation Arrays |
Dr. A. Leonardo Iniguez, Roche NimbleGen |
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| Jan 15, 2009 |
NimbleGen Sequence Capture Using the HD2 Platform: Exome Capture Made Easy |
Dr. Dan Burgess, Roche NimbleGen |
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| Nov 6, 2008 |
Introducing NimbleGen HD2 Arrays for High-Resolution ChIP-chip Analysis |
Dr. A. Leonardo Iniguez, Roche NimbleGen |
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| Apr 3, 2008 |
Sequence Capture Technology: Using Microarrays to Capture Megabases of Sequence or Hundreds of Thousands of Human Exons for Next Generation Sequencing |
Dr. Tom Albert, Roche NimbleGen |
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| Mar 19, 2008 |
Genomic Analyses of Gene Regulation by Poly(ADP-Ribose) Polymerase-1 and Histone H1 |
Dr. Matt Gamble, Cornell University |
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| Feb 28, 2008 |
Integrated Epigenomic Analyses of Neuronal MeCP2 Reveal a Role for Long-Range Interaction with Active Genes |
Dr. Janine LaSalle, UC Davis |
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| Nov 29, 2007 |
Genome Architecture and Genomic Disease: A Targeted Approach to Disease Discovery |
Dr. Heather Mefford University of Washington |
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| Nov 1, 2007 |
Demonstration of KAP1 Binding to Silenced Chromatin with Genome-wide ChIP-chip Analysis |
Dr. Henriette O'Geen University of California, Davis |
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| Sep 19, 2007 |
Gene Silencing by Large, Non-coding RNAs: The Regulatory Role of HOTAIR analyzed with ChIP-chip and Tiling Expression Analysis |
Dr. John Rinn, Harvard Medical School |
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| Aug 15, 2007 |
Assaying Gene Expression Using NimbleGen Multiplex Arrays: Taking Advantage of High-Throughput Sample Analysis |
Dr. John Manak, Roche NimbleGen |
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| Jul 18, 2007 |
Genome-Wide Distribution, Sequence Determinant and Evolution of CTCF Binding |
Dr. Tae Hoon Kim, Yale University School of Medicine |
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| May 17, 2007 |
MIRA-Assisted Microarrays for DNA Methylation Analysis and Cancer Diagnosis |
Dr. Gerd Pfeifer, Beckman Research Institute, City of Hope |
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| May 8, 2007 |
Microarray-Mediated, Whole-Genome Comparison of the Distribution of RNA Polymerase with the Transcript Map in Escherichia coli |
Dr. Joseph Wade, Harvard University |
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| Apr 11, 2007 |
Part I: A novel genomic disorder affecting neurobehavioral development; fine mapping of rearrangements involving complex low copy repeats on chromosome 10q |
Dr. Scott Selleck, The University of Minnesota |
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| Apr 11, 2007 |
Part II: Using Drosophila to model disruptions of PTEN-TSC-TOR signaling on synapse assembly and behavior |
Dr. Scott Selleck, The University of Minnesota |
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| Mar 13, 2007 |
Efficient High-Resolution Deletion Discovery in Caenorhabditis elegans by Array CGH |
Dr. Jason Maydan, UBC, Vancouver, BC, Canada |
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| Mar 6, 2007 |
Using High-Resolution ChIP-chip to Model Chromatin Signatures of Promoters and Enhancers in the Human Genome |
Dr. Nathaniel Henitzman, LICR, UCSD |
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| Feb 15, 2007 |
High-Resolution Mapping of Copy-Number Variants Genome-Wide with Array CGH |
Timothy A. Graubert, M.D. Washington University, St. Louis |
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| Jan 24, 2007 |
Genome-Wide DNA Methylation Analysis with Immunoprecipitation and Tiling DNA Microarrays |
Dr. Daniel Zilberman, Fred Hutchinson Cancer Research Center |
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| Aug 31, 2006 |
The Discovery and Characterization of Genomic Disorders with High-Resolution Array CGH |
Dr. Andrew Sharp, The University of Washington |
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| Aug 8, 2006 |
AHigh-Resolution Method to Identify DNase I Hypersensitive Sites Using Tiled Microarrays |
Dr. Greg Crawford, Duke University |
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| May 16, 2006 |
Genome-Wide Mapping of Transcriptional Regulatory Elements in Mammalian Cells |
Dr. Bing Ren, UCSD |
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| Feb 6, 2006 |
Identifying Antibiotic Resistance and Other Adaptive Mutations in Helicobacter pylori using NimbleGen CGS Technology |
Dr. Douglas Berg, Washington University |
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Roche NimbleGen Workshops 
| Date |
Venue |
Topic |
Speaker |
Download Audio Podcast |
Download Video Podcast |
View Flash Movie |
| Jan 13, 2009 |
PAG 2009 |
Empirical Annotation of Genomes by Differential Expression Analysis of Transcriptionally Active Regions |
Dr. John Colbourne Indiana University |
Audio and Video Files Available - Summer 2009 |
| Whole Genome Analysis of DNA Copy Number Variation in Dogs |
Dr. Carlos E. Alvarez Ohio State University |
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| Discovery of Human Genetic Variations with Sequence Capture Technology |
Dr. Nathan M. Springer University of Minnesota |
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| Nov 12, 2008 |
ASHG 2008 |
Copy Number Variation in Low Copy Repeat-Rich Regions of the Genome: How Much is There and What Does it Take to Measure It? |
Dr. Scott Selleck University of Minnesota |
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| Distinct Chromatin Modifications at Enhancers Correlate with Cell Type-Specific Gene Expression in the Human Genome |
Dr. David Hawkins University of California - San Diego |
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| Discovery of Human Genetic Variations with Sequence Capture Technology |
Matthew Bainbridge MS Student Baylor College of Medicine |
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| Jun 2, 2007 |
ESHG 2008 |
High-Throughput Detection of Exonic Copy-Number Changes Using NimbleGen Oligonucleotide-Based CGH Array Technology |
Dr. Jamel Chelly Institute Cochin - Hospital Cochin |
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| High-Throughput Approaches for DNA Methylation Profiling |
Dr. Stephan Beck University College London |
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| Sequence Capture for Medical Sequencing |
Dr. Daniel Turner Wellcome Trust Sanger Institute |
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| Jan 15, 2008 |
PAG 2008 |
Genome-Scale Targeted Sequencing and Expression Analysis in Duplicated Genomes |
Full Program |
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Direct Genomic Selection by Microarray Hybridization for High-Throughput Sequencing |
Dr. Xinmin Zhang, Roche NimbleGen |
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| Insights into the Evolutionary Significance of Whole Genome Duplications Provided by Populus Expression Arrays |
Dr. Steve DiFazio, West Virginia University |
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| Duplicate gene expression evolution in cotton |
Lex Flagel, PhD Student
Iowa State University |
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| Oct 25, 2007 |
ASHG 2007 |
NimbleGen Genetics & Epigenetics Workshop, Full Program |
Full Program |
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| Genome-wide scan of copy number variation in autism |
Dr. Jonathan Sebat Cold Spring Harbor Laboratory |
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| Epigenetic Regulation of the HOX Locus by Non-coding RNAs |
Dr. John Rinn, Harvard Medical School |
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| Application of CGH arrays in DNA Diagnostics |
Dr.Madhuri Hegde Emory University School of Medicine |
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| Jun 18, 2007 |
ESHG 2007 |
Human Genetics and Epigenetics: High-Resolution Discovery with Array CGH, DNA Methylation, and ChIP-chip |
Full Program |
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| Towards a comprehensive map of copy number variation in the human genome |
Dr. Matthew Hurles The Wellcome Trust Sanger Institute, Cambridge |
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Mapping promoter DNA methylation in mammalian genomes using oligonucleotide arrays |
Dr. Michaƫl Weber Friedrich Miescher Institute for Biomedical Research, Basel |
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| Combinatorial Effects of Four Histone Modifications in Transcription and Differentiation |
Dr. Silke Sperling Max Planck Institute for Molecular Genetics, Berlin |
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| Mar 24, 2007 |
ACMG 2007 |
Detection of Microdeletion and Microduplication Disorders Using Ultra-High Resolution array CGH |
Dr. Blake Ballif, Signature Genomic Labs, LLC |
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| Oct 10, 2006 |
ASHG 2006 |
Human Genetics and Epigenetics: High-Resolution Discovery with Array CGH, DNA Methylation, and ChIP-chip |
Full Program |
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| The Discovery and Characterization of Genomic Disorders with High-Resolution Array CGH |
Dr. Andrew Sharp, The University of Washington |
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| Cytosine Methylation Dynamics in Development and Disease |
Dr. John Greally, Albert Einstein College of Medicine |
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| ChIP-Chip'ing Away at the Functions of Proteins Mutated in Genetic Syndromes |
Dr. Peter C. Scacheri, Case Western Reserve University |
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Listening to the Audio Podcasts
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 Viewing the video Podcasts requires Apple iTunes and a fifth generation video-capable iPod or an Apple iPhone. You have the option of subscribing to the NimbleGen Systems Webinar Series through iTunes or downloading the podcast files individually and opening them with iTunes. You can view the files on your desktop with iTunes or transfer them to your iPod for portability. They are posted in an MPEG-4 video file format.
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 Viewing the video of the Roche NimbleGen webinars and workshops requires the Adobe Flash Plugin.
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