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Roche NimbleGen Webinars and Workshops

Recent Webinars

A. Leonardo Iniguez, Ph. D.
Senior Scientist, Epigenetics
Roche NimbleGen
Madison, WI
Thursday, April 9, 2009
Introducing the High-Resolution, High-Sensitivity NimbleGen 2.1M DNA Methylation Arrays
Epigenetic mechanisms, such as DNA methylation, play critical roles in the regulation of gene expression. Understanding DNA methylation will not only further our knowledge of gene regulation, but given the connection between epigenetics and disease, it will also increase our understanding of disease development hopefully leading to the creation of diagnostics as well as preventative and therapeutic treatment options. Powerful methods exist to analyze DNA methylation patterns in higher eukaryotes including methylated DNA immunoprecipitation (MeDIP), an affinity based approach to enrich methylated DNA regions from genomic DNA, which can be combined with microarrays to profile genomic DNA methylation patterns. Here we introduce our new, MeDIP-optimized, 2.1M DNA Methylation Array portfolio for human, mouse and rat including our whole genome tiling array sets (10-array sets at 100bp probe spacing or 4-array sets at ~200bp probe spacing) and the Deluxe Promoter Arrays which offer the most comprehensive gene promoter, CpG island, and miRNA promoter coverage available in a single slide array. The new human and mouse DNA methylation arrays also include probes covering positive, negative and nonCpG control regions to aid in assessment of experimental performance. We will demonstrate (1) the comprehensive, sensitive, reproducible DNA methylation analysis possible using MeDIP and the 2.1M DNA Methylation arrays, (2) the utility of the control regions in analyzing MeDIP experimental performance, and (3) the validation of whole-genome MeDIP-chip analysis using bisulphite conversion and sequencing.
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Roche NimbleGen Webinar Series
Date Topic Speaker Download Audio Podcast Download Video Podcast View Flash Movie
Apr 9, 2009 Introducing the High-Resolution, High-Sensitivity NimbleGen 2.1M DNA Methylation Arrays Dr. A. Leonardo Iniguez,
Roche NimbleGen
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Jan 15, 2009 NimbleGen Sequence Capture Using the HD2 Platform: Exome Capture Made Easy Dr. Dan Burgess,
Roche NimbleGen
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Nov 6, 2008 Introducing NimbleGen HD2 Arrays for High-Resolution ChIP-chip Analysis Dr. A. Leonardo Iniguez,
Roche NimbleGen
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Apr 3, 2008 Sequence Capture Technology: Using Microarrays to Capture Megabases of Sequence or Hundreds of Thousands of Human Exons for Next Generation Sequencing Dr. Tom Albert,
Roche NimbleGen
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Mar 19, 2008 Genomic Analyses of Gene Regulation by Poly(ADP-Ribose) Polymerase-1 and Histone H1 Dr. Matt Gamble,
Cornell University
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Feb 28, 2008 Integrated Epigenomic Analyses of Neuronal MeCP2 Reveal a Role for Long-Range Interaction with Active Genes Dr. Janine LaSalle,
UC Davis
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Nov 29, 2007 Genome Architecture and Genomic Disease: A Targeted Approach to Disease Discovery Dr. Heather Mefford
University of Washington
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Nov 1, 2007 Demonstration of KAP1 Binding to Silenced Chromatin with Genome-wide ChIP-chip Analysis Dr. Henriette O'Geen
University of California, Davis
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Sep 19, 2007 Gene Silencing by Large, Non-coding RNAs: The Regulatory Role of HOTAIR analyzed with ChIP-chip and Tiling Expression Analysis Dr. John Rinn, Harvard Medical School Download Audio Podcast Download Video Podcast View Flash Movie
Aug 15, 2007 Assaying Gene Expression Using NimbleGen Multiplex Arrays: Taking Advantage of High-Throughput Sample Analysis Dr. John Manak, Roche NimbleGen Download Audio Podcast Download Video Podcast View Flash Movie
Jul 18, 2007 Genome-Wide Distribution, Sequence Determinant and Evolution of CTCF Binding Dr. Tae Hoon Kim, Yale University School of Medicine Download Audio Podcast Download Video Podcast View Flash Movie
May 17, 2007 MIRA-Assisted Microarrays for DNA Methylation Analysis and Cancer Diagnosis Dr. Gerd Pfeifer, Beckman Research Institute, City of Hope Download Audio Podcast Download Video Podcast View Flash Movie
May 8, 2007 Microarray-Mediated, Whole-Genome Comparison of the Distribution of RNA Polymerase with the Transcript Map in Escherichia coli Dr. Joseph Wade, Harvard University Download Audio Podcast Download Video Podcast View Flash Movie
Apr 11, 2007 Part I: A novel genomic disorder affecting neurobehavioral development; fine mapping of rearrangements involving complex low copy repeats on chromosome 10q Dr. Scott Selleck, The University of Minnesota Download Audio Podcast Download Video Podcast View Flash Movie
Apr 11, 2007 Part II: Using Drosophila to model disruptions of PTEN-TSC-TOR signaling on synapse assembly and behavior Dr. Scott Selleck, The University of Minnesota Download Audio Podcast Download Video Podcast View Flash Movie
Mar 13, 2007 Efficient High-Resolution Deletion Discovery in Caenorhabditis elegans by Array CGH Dr. Jason Maydan, UBC, Vancouver, BC, Canada Download Audio Podcast Download Video Podcast View Flash Movie
Mar 6, 2007 Using High-Resolution ChIP-chip to Model Chromatin Signatures of Promoters and Enhancers in the Human Genome Dr. Nathaniel Henitzman, LICR, UCSD Download Audio Podcast Download Video Podcast View Flash Movie
Feb 15, 2007 High-Resolution Mapping of Copy-Number Variants Genome-Wide with Array CGH Timothy A. Graubert, M.D. Washington University, St. Louis Download Audio Podcast Download Video Podcast View Flash Movie
Jan 24, 2007 Genome-Wide DNA Methylation Analysis with Immunoprecipitation and Tiling DNA Microarrays Dr. Daniel Zilberman, Fred Hutchinson Cancer Research Center Download Audio Podcast Download Video Podcast View Flash Movie
Aug 31, 2006 The Discovery and Characterization of Genomic Disorders with High-Resolution Array CGH Dr. Andrew Sharp, The University of Washington Download Audio Podcast Download Video Podcast View Flash Movie
Aug 8, 2006 AHigh-Resolution Method to Identify DNase I Hypersensitive Sites Using Tiled Microarrays Dr. Greg Crawford, Duke University Download Audio Podcast Download Video Podcast View Flash Movie
May 16, 2006 Genome-Wide Mapping of Transcriptional Regulatory Elements in Mammalian Cells Dr. Bing Ren, UCSD Download Audio Podcast Download Video Podcast View Flash Movie
Feb 6, 2006 Identifying Antibiotic Resistance and Other Adaptive Mutations in Helicobacter pylori using NimbleGen CGS Technology Dr. Douglas Berg, Washington University Download Audio Podcast Download Video Podcast View Flash Movie
Roche NimbleGen Workshops
Date Venue Topic Speaker Download Audio Podcast Download Video Podcast View Flash Movie
Jan 13, 2009 PAG 2009 Empirical Annotation of Genomes by Differential Expression Analysis of Transcriptionally Active Regions Dr. John Colbourne
Indiana University
Audio and Video Files Available - Summer 2009
Whole Genome Analysis of DNA Copy Number Variation in Dogs Dr. Carlos E. Alvarez
Ohio State University
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Discovery of Human Genetic Variations with Sequence Capture Technology Dr. Nathan M. Springer
University of Minnesota
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Nov 12, 2008 ASHG 2008 Copy Number Variation in Low Copy Repeat-Rich Regions of the Genome: How Much is There and What Does it Take to Measure It? Dr. Scott Selleck
University of Minnesota
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Distinct Chromatin Modifications at Enhancers Correlate with Cell Type-Specific Gene Expression in the Human Genome Dr. David Hawkins
University of California - San Diego
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Discovery of Human Genetic Variations with Sequence Capture Technology Matthew Bainbridge
MS Student
Baylor College of Medicine
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Jun 2, 2007 ESHG 2008 High-Throughput Detection of Exonic Copy-Number Changes Using NimbleGen Oligonucleotide-Based CGH Array Technology Dr. Jamel Chelly
Institute Cochin - Hospital Cochin
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High-Throughput Approaches for DNA Methylation Profiling Dr. Stephan Beck
University College London
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Sequence Capture for Medical Sequencing Dr. Daniel Turner
Wellcome Trust Sanger Institute
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Jan 15, 2008 PAG 2008 Genome-Scale Targeted Sequencing and Expression Analysis in Duplicated Genomes Full Program Download Audio Podcast Download Video Podcast View Flash Movie
Direct Genomic Selection by Microarray Hybridization for
High-Throughput Sequencing
Dr. Xinmin Zhang,
Roche NimbleGen
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Insights into the Evolutionary Significance of Whole Genome Duplications Provided by Populus Expression Arrays Dr. Steve DiFazio,
West Virginia University
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Duplicate gene expression evolution in cotton Lex Flagel,
PhD Student
Iowa State University
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Oct 25, 2007 ASHG 2007 NimbleGen Genetics & Epigenetics Workshop, Full Program Full Program Download Audio Podcast Download Video Podcast View Flash Movie
Genome-wide scan of copy number variation in autism Dr. Jonathan Sebat
Cold Spring Harbor Laboratory
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Epigenetic Regulation of the HOX Locus by Non-coding RNAs Dr. John Rinn, Harvard Medical School Download Audio Podcast Download Video Podcast View Flash Movie
Application of CGH arrays in DNA Diagnostics Dr.Madhuri Hegde
Emory University School of Medicine
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Jun 18, 2007 ESHG 2007 Human Genetics and Epigenetics:
High-Resolution Discovery with Array CGH, DNA Methylation, and ChIP-chip
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Towards a comprehensive map of copy number variation in the human genome Dr. Matthew Hurles
The Wellcome Trust Sanger Institute, Cambridge
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Mapping promoter DNA
methylation in mammalian
genomes using oligonucleotide
arrays
Dr. Michaƫl Weber
Friedrich Miescher Institute for Biomedical Research, Basel
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Combinatorial Effects of Four Histone Modifications in Transcription and Differentiation Dr. Silke Sperling
Max Planck Institute for Molecular Genetics, Berlin
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Mar 24, 2007 ACMG 2007 Detection of Microdeletion and Microduplication Disorders Using Ultra-High Resolution array CGH Dr. Blake Ballif, Signature Genomic Labs, LLC Download Audio Podcast Download Video Podcast View Flash Movie
Oct 10, 2006 ASHG 2006 Human Genetics and Epigenetics: High-Resolution Discovery with Array CGH, DNA Methylation, and ChIP-chip Full Program Download Audio Podcast Download Video Podcast View Flash Movie
The Discovery and Characterization of Genomic Disorders with High-Resolution Array CGH Dr. Andrew Sharp, The University of Washington Download Audio Podcast Download Video Podcast View Flash Movie
Cytosine Methylation Dynamics in Development and Disease Dr. John Greally, Albert Einstein College of Medicine Download Audio Podcast Download Video Podcast View Flash Movie
ChIP-Chip'ing Away at the Functions of Proteins Mutated in Genetic Syndromes Dr. Peter C. Scacheri, Case Western Reserve University Download Audio Podcast Download Video Podcast View Flash Movie
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